Millipore Pro Flux M30 Tangential Flow Filtration System

• Concentration and diafiltration of proteins, antibodies, and vaccines.
• Clarification of cell cultures and fermentation broths.
• Virus filtration and removal in biopharmaceutical manufacturing.
• Sample preparation for analytical and purification steps.
• Buffer exchange and desalting of biomolecules.

Typical capacity

For this class of system, it typically handles volumes from 1 to 30 litres, depending on membrane area and application.

Power supply

Commonly requires a standard single-phase electrical supply, typically 230V, 50Hz for UK operation.

Membrane compatibility

Units of this type are compatible with a wide range of flat sheet or hollow fibre membranes from various manufacturers, offering flexibility in molecular weight cut-offs and chemistries.

Construction material

Typically features wetted parts constructed from 316L stainless steel and sanitary elastomers, suitable for pharmaceutical applications.

Control system

Commonly includes integrated controls for transmembrane pressure (TMP), flow rate, and temperature, often with a user-friendly interface.

Footprint

For a laboratory-scale unit, the footprint is typically compact, designed for benchtop or mobile cart placement.

• What is Tangential Flow Filtration (TFF)?

  TFF is a filtration method where the feed stream flows tangentially across the surface of a membrane, rather than perpendicularly through it. This minimises membrane fouling and allows for continuous processing.

• What are the primary benefits of using a TFF system like the Pro Flux M30?

• Can this system be used for both research and production?

• What kind of maintenance does a TFF system require?

• Is this system suitable for sterile applications?

Separators and extraction systems are valued for their reliability in sample preparation workflows across laboratory and pharmaceutical settings. Buyers typically seek equipment with robust construction and minimal downtime history. Key considerations when purchasing used units include chamber integrity, seal condition, and calibration documentation. Industry sentiment favours models offering consistent reproducibility and easy maintenance. Established brands generally command confidence due to parts availability and technical support, though thorough inspection and performance testing remain essential before purchase.

General overview for this equipment type